This system of medicine was developed from the principles of Homeopathy by Hans-Heinrich Reckeweg in 1948/49. Reckeweg took the fundamentals of Hahnemann's ideas on homeopathy and combined them with conventional medicine to produce a new and original therapeutic method and theory of disease.

Homotoxicology holds that every healthy organism (animal or human) exists in a dynamic state of equilibrium which is disturbed whenever noxious stimuli (homotoxins) overwhelm the body, or cannot be eliminated due to metabolic disorders. Depending on the severity and/or duration of the toxicity, blockages and immune responses develop, which eventually show as visible symptoms of illness. Toxins are deposited and stored in the sponge-like ground substance of the connective tissue (matrix) where they interfere with the transport of nutrients and waste in and out of cells - a first step in the development of pathological changes.

Homotoxicological medicines are designed to clear the matrix of these toxins so that the body may resume its normal function. Different types of complexes are used according to the severity of disease which is present, and may be given orally or by injection, or in a combination of these.